Toxicologic Pathology: A Primer 1st Edition

Toxicologic Pathology: A Primer - Your Essential Guide to Nonclinical Safety

This book is a practical, easy-to-use reference designed to be the first basic overview covering the field of toxicologic pathology. It contains the core, underlying principles of the discipline, making it valuable to the veterinary pathology student considering a career in the field and serving as a succinct refresher for the seasoned toxicologic pathologist.

Key Features

• Core Principles and Concepts: The book introduces the basic, underlying principles of toxicologic pathology, including an overview chapter covering the field and a "concept" chapter describing its role in drug development.
• Systematic Organization: The Primer is arranged as chapters presenting each major organ system. These chapters provide histopathologic descriptions of lesions observed in toxicity studies and testing of chemicals that may negatively impact the environment.
• Lesion Significance: Each organ system chapter provides additional information related to a particular lesion to aid the reader in better understanding its toxicologic significance relative to human risk.
• Chapter Structure: Each organ system chapter is consistently structured, containing:
  • A brief introduction.
  • A succinct description of the anatomy and physiology of the system.
  • Descriptions of the most important pathological lesions.
  • Differential diagnoses.
  • Biological consequences, pathogenesis, and/or mechanism of lesion formation.
  • Associated clinical pathology correlates.
• Broad Audience: This Primer is useful for nonclinical safety scientists (like study directors and senior toxicology report reviewers), scientific management of Contract Research Organizations (CROs), and students.